Fennel (Foeniculum vulgare Mill.)
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Fennel/Drug Interactions:- Anticoagulant drugsAnticoagulant drugs: Ferula communis (giant fennel) contains a potent anticoagulant and induces severe hemorrhagic diathesis in grazing ewes, or similar changes in utero in lambs (30). This may potentiate the effects of other anticoagulants.
- Ciprofloxacin (Cipro®)Ciprofloxacin (Cipro®): Concurrent use of fennel and ciprofloxacin may lead to decreased bioavailability of ciprofloxacin. Fennel contains high amounts of minerals and the formation of a ciprofloxacin cation complex results. This formation reduces ciprofloxacin absorption. Simultaneous use of these agents leads to an 83% reduction in ciprofloxacin Cmax while Tmax remains unaffected. The total clearance of ciprofloxacin is increased 20-fold. There is a reduction in the volume of distribution and area under the curve, and the elimination half-life is prolonged 2.7 fold (31). Theoretically, fennel may also interfere similarly with other fluoroquinolone antibiotics.
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Fennel/Herb/Supplement Interactions:- Anticoagulant herbs & supplementsAnticoagulant herbs & supplements: Theoretically, fennel may increase the effects of anticoagulant herbs and supplements.
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Fennel/Food Interactions:- Insufficient available evidence.
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Fennel/Lab Interactions:- Insufficient available evidence.
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Copyright © 2011 Natural Standard (www.naturalstandard.com)
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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
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