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Methionine/Nutrient Depletions:- Antineoplastic agentsAntineoplastic agents: In mice, methionine depletion increased the efficacy of cisplatin against the MX-t human breast carcinoma cell line (11) and significantly enhanced the antitumor activity of 5-fluorouracil against the SC-1-NU human gastric cancer xenograft by approximately twofold (12). Synergy between methionine restriction and 5-fluorouracil may be attributable to multiple factors, including depletion of reduced folates, selective inhibition of thymidylate synthase, and creation of an imbalanced nucleotide pool (26).
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Copyright © 2011 Natural Standard (www.naturalstandard.com)
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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
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