Longevity*, Joint Strength*, Liver Detoxification*, Mood and Brain Function
Jarrow FORMULAS® SAM-e 200 is foil blister-packed to maximize stability and safety. Do not use if outer seal of blister pack is broken.
Full Potency 200 mg elemental SAM-e is derived from 400 mg of tosylate disulfate SAM-e.
Store in a cool, dry place.
Jarrow FORMULAS® SAM-e 200 pharmaceutical grade, stabilized SAM-e provides a full 200 mg elemental SAM-e from 400 mg of SAM-e tosylate disulfate. SAM-e 200 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.
Contains More of the Active S,S Form
SAM-e (S-Adenosylmethionine) is a chiral molecule and therefore consists of two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow FORMULAS' SAM-e is made naturally by microbiological fermentation and then specially processed without solvents to preserve 68-80% (S,S) SAM-e, the highest active level available. SAM-e is an amino acid derivative that has been clinically proven to benefit brain, joint and liver function.* Found in all living cells, SAM-e is often referred to as “activated” methionine (an essential amino acid) since it is formed by the combining of ATP with methionine. SAM-e has undergone dozens of trials involving thousands of patients. Researchers studying the beneficial effects of SAM-e have identified the following benefits of SAM-e:
SAM-e supports the production of healthy connective tissue through transulfuration. In this process, critical components of connective tissue, including glucosamine and the chondroitin sulfates, are sulfated by SAM-e metabolites.*
SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-dopa, dopamine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component of lecithin).*
Methylation of DNA appears to be important in the suppression of errors in DNA replication. Demethylation of DNA is considered a contributor to the aging process. Proper methylation through substances such as SAM-e positively influences longevity.*
SAM-e metabolism supports the synthesis of glutathione (GSH) and glutathione -dependent enzymes (glutathione peroxidase and glutathione-S-transferase), which are substances important for liver function.*
DetoxificationSupplemental SAM counteracts the Anxiety and Depression commonly experienced by persons with Drug Dependence during the detoxification and rehabilitation period [scientific research - humans: 1,200 mg of SAM per day significantly reduced the psychological stress encountered by former Opiate users during their detoxification period].Digestive SystemSupplemental SAM stimulates the flow of Bile. Supplemental SAM (600 - 800 mg per day) helps to prevent Cholestasis (by improving the flow of Bile) [scientific research].Immune SystemPersons afflicted with Acquired Immune Deficiency Syndrome (AIDS) have low endogenous Cerebrospinal Fluid (CSF) levels of SAM and for this reason supplemental SAM is under investigation as a potential treatment for AIDS [scientific research - humans]. Supplemental SAM helps to protect against Liver Cancer in persons exposed to Liver carcinogens [scientific research - rats].MetabolismSupplemental SAM enhances the health of and normalizes the function of the Liver:- Supplemental SAM inhibits Alcohol-induced Liver damage [scientific research- monkeys]:- Supplemental SAM can prevent and cure Cirrhosis.- Supplemental SAM can prevent and cure Fatty Liver.Supplemental SAM reduces the elevated Bilirubin levels that are associated with Gilbert’s Syndrome [scientific research - humans: 400 mg of SAM administered 3 times per day (=1,200 mg per day) results in a significant decreases in elevated Bilirubin levels]. SAM functions in over 40 biochemical reactions within the body - it functions as a Methyl Donor.Musculoskeletal SystemSupplemental SAM enhances the differentiation of Chondrocytes into Chondroblasts (and Chondrocytes) [scientific research - in vitro]. Supplemental SAM (800 mg per day) alleviates Fibromyalgia [scientific research - humans: 800 mg of supplemental SAM per day caused a significant reduction in the number of trigger points, reduction in Fatigue, reduction in morning stiffness and improvements in Mood in Fibromyalgia patients].Supplemental SAM alleviates Osteoarthritis [scientific research]. Supplemental SAM alleviates Fibrositis [scientific research].Nervous SystemPersons afflicted with Alzheimer’s Disease exhibit severely decreased levels of SAM within their Brains (indicating that supplemental SAM may be highly beneficial to Alzheimer’s Disease patients) [scientific research - humans] [further note: it was previously (prior to 1995) assumed that Alzheimer’s Disease patients had excessive accumulation of SAM - this assumption has now proven erroneous].SAM is an essential factor for the regeneration of Axons on Neurons following injury and is also essential for the formation of Myelin Sheaths that surround Axons [scientific research]. Supplemental SAM alleviates all forms of Depression [scientific research - humans: many studies have confirmed that SAM is significantly (approximately 15%) more effective in the treatment of Depression than traditional Pharmaceutical Anti-Depressants for the treatment of Depression]:- SAM alleviates Major Depression [scientific research - humans].- SAM is especially effective in treating Postpartum Depression.Supplemental SAM is presently under investigation as a potential treatment for Parkinson’s Disease [scientific research - humans: Parkinson’s Disease patients have endogenous levels of SAM that are only 60% of the levels of those of healthy subjects].